Role of receptor binding specificity in influenza A virus transmission and pathogenesis
Identifieur interne : 000763 ( Main/Exploration ); précédent : 000762; suivant : 000764Role of receptor binding specificity in influenza A virus transmission and pathogenesis
Auteurs : Miranda De Graaf [Pays-Bas] ; Ron A M. Fouchier [Pays-Bas]Source :
- The EMBO Journal [ 0261-4189 ] ; 2014-04-16.
Abstract
The recent emergence of a novel avian A/H7N9 influenza virus in poultry and humans in China, as well as laboratory studies on adaptation and transmission of avian A/H5N1 influenza viruses, has shed new light on influenza virus adaptation to mammals. One of the biological traits required for animal influenza viruses to cross the species barrier that received considerable attention in animal model studies, in vitro assays, and structural analyses is receptor binding specificity. Sialylated glycans present on the apical surface of host cells can function as receptors for the influenza virus hemagglutinin (HA) protein. Avian and human influenza viruses typically have a different sialic acid (SA)‐binding preference and only few amino acid changes in the HA protein can cause a switch from avian to human receptor specificity. Recent experiments using glycan arrays, virus histochemistry, animal models, and structural analyses of HA have added a wealth of knowledge on receptor binding specificity. Here, we review recent data on the interaction between influenza virus HA and SA receptors of the host, and the impact on virus host range, pathogenesis, and transmission. Remaining challenges and future research priorities are also discussed.
Recent cases of humans carrying avian Influenza strains highlight the importance of unraveling the role of virus‐receptor interactions in cross‐species adaptation. de Graaf and Fouchier review how virus hemagglutinin binding to host receptors governs virus pathogenesis, transmission and host spectrum.
Url:
- https://api.istex.fr/ark:/67375/WNG-MN2HR12X-0/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194109
DOI: 10.1002/embj.201387442
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000398
- to stream Istex, to step Curation: 000398
- to stream Istex, to step Checkpoint: 000027
- to stream Pmc, to step Corpus: 000C81
- to stream Pmc, to step Curation: 000C81
- to stream Pmc, to step Checkpoint: 000457
- to stream Ncbi, to step Merge: 000A24
- to stream Ncbi, to step Curation: 000A24
- to stream Ncbi, to step Checkpoint: 000A24
- to stream Main, to step Merge: 000764
- to stream Main, to step Curation: 000763
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of receptor binding specificity in influenza A virus transmission and pathogenesis</title><author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D850D247DF3F16806DCFF3C87D20704C5DCD9A0D</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/embj.201387442</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-MN2HR12X-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000398</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000398</idno><idno type="wicri:Area/Istex/Curation">000398</idno><idno type="wicri:Area/Istex/Checkpoint">000027</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000027</idno><idno type="wicri:doubleKey">0261-4189:2014:De Graaf M:role:of:receptor</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194109</idno><idno type="RBID">PMC:4194109</idno><idno type="wicri:Area/Pmc/Corpus">000C81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C81</idno><idno type="wicri:Area/Pmc/Curation">000C81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C81</idno><idno type="wicri:Area/Pmc/Checkpoint">000457</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000457</idno><idno type="wicri:Area/Ncbi/Merge">000A24</idno><idno type="wicri:Area/Ncbi/Curation">000A24</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A24</idno><idno type="wicri:doubleKey">0261-4189:2014:De Graaf M:role:of:receptor</idno><idno type="wicri:Area/Main/Merge">000764</idno><idno type="wicri:Area/Main/Curation">000763</idno><idno type="wicri:Area/Main/Exploration">000763</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Role of receptor binding specificity in influenza A virus transmission and pathogenesis</title><author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The EMBO Journal</title><title level="j" type="alt">THE EMBO JOURNAL</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="823">823</biblScope><biblScope unit="page" to="841">841</biblScope><biblScope unit="page-count">18</biblScope><date type="published" when="2014-04-16">2014-04-16</date></imprint><idno type="ISSN">0261-4189</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0261-4189</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The recent emergence of a novel avian A/H7N9 influenza virus in poultry and humans in China, as well as laboratory studies on adaptation and transmission of avian A/H5N1 influenza viruses, has shed new light on influenza virus adaptation to mammals. One of the biological traits required for animal influenza viruses to cross the species barrier that received considerable attention in animal model studies, in vitro assays, and structural analyses is receptor binding specificity. Sialylated glycans present on the apical surface of host cells can function as receptors for the influenza virus hemagglutinin (HA) protein. Avian and human influenza viruses typically have a different sialic acid (SA)‐binding preference and only few amino acid changes in the HA protein can cause a switch from avian to human receptor specificity. Recent experiments using glycan arrays, virus histochemistry, animal models, and structural analyses of HA have added a wealth of knowledge on receptor binding specificity. Here, we review recent data on the interaction between influenza virus HA and SA receptors of the host, and the impact on virus host range, pathogenesis, and transmission. Remaining challenges and future research priorities are also discussed.</div><div type="abstract">Recent cases of humans carrying avian Influenza strains highlight the importance of unraveling the role of virus‐receptor interactions in cross‐species adaptation. de Graaf and Fouchier review how virus hemagglutinin binding to host receptors governs virus pathogenesis, transmission and host spectrum.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name></region><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000763 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000763 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D850D247DF3F16806DCFF3C87D20704C5DCD9A0D
|texte= Role of receptor binding specificity in influenza A virus transmission and pathogenesis
}}
| This area was generated with Dilib version V0.6.33. |  |